3D Complex is a hierarchical classification of protein complexes that describes similarities in structure, sequence, as well as topology of contacts of the constituent proteins. This is the first automatic method for generating non-redundant sets of complexes, which can be used to derive unbiased statistics on their structure and evolution. If you would like to refer to 3DComplex, please cite:
Levy ED, Pereira-Leal JB, Chothia C, Teichmann SA, 3D complex: a structural classification of protein complexes. PLoS Comput Biol. 2006 Nov 17;2(11):e155. Epub 2006 Oct 5
Main features of this server
Through this Web Server, you can:
- Browse the classification of protein complexes,
- Search for protein complexes according various attributes,
- Download non-rednundant sets of protein complexes (e.g. all hetero- or homodimers in PDB) at various similarity thresholds,
3D Complex v6.0 Several features have been added in this new release!
- Generally, the back-end has been extensively re-worked to provide you with more frequent updates.
- Domain definitions are still based on SCOP and PFAM
- In addition, domain definitions from ECOD have been incorporated to maximize coverage, with the current release containing >170K assemblies.
- PiQSi is updated with matching 3DComplex information.
- Data from QSbio are being integrated to provide highly accurate information on quaternary structure.
- Roll over a graph image and a menu will pop-up, which allows you, to search in one click all structures containing a similar chain, or domain to the one you selected.
- The definition of the hierarchy has been revised to provide more accurate non-redundant sets. We recommend you to look at the documentation of this release for more details.
- Finally, you can try the Quick Search: