Legend

%id Code Chains Pic Error? Sym Nsub Sprot Weight Ref H E R Org Fun
% seq. id. PDB Code query & target Graph picture Is the current PDB state judged to be an error? Symmetry No. subunits SwissProt link No. of amino acids (per chain) Pubmed ID Get Homologs Edit Structure View structure Organism Function
NOTE: roll over NO, PROBNOT or YES, PROBYES to read PiQSi annotation, and roll over the PDB name to read its title.

Protein reference

Code Pic Error? Sym1 Nsub1 Sym2 Nsub2 Error_auto? Sym_auto Nsub_auto SProt Weight Ref H E R Org Fun
PDBPiQSi
3m0d_2? NPS4??- --Q12933PHERHomo sapiensSIGNALING PROTEIN

Homologs

%id Code Chains Pic Error? Sym1 Nsub1 Sym2 Nsub2 Error_auto Sym_auto Nsub_auto SProt Weight Ref H E R Org Fun
893m1d_1D & A? NPS1??? Q13490PHERHomo sapiensMETAL BINDING PROTEIN
893m1d_2D & B? NPS1??? Q13490PHERHomo sapiensMETAL BINDING PROTEIN
503d9t_1D & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS
503d9t_2D & B? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS
503d9u_1D & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS
503mup_1D & A? C24??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
503oz1_1D & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
503oz1_2D & B? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
503oz1_3D & C? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
503oz1_4D & D? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
504eb9_1D & A? C22??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
504eb9_2D & D? C22??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
504hy4_1D & A? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
504hy4_2D & B? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
504hy5_1D & A? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
504hy5_2D & B? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
504kmn_1D & A? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
504lge_1D & A? NPS1??? Q13490PHERHomo sapiensLigase/Ligase inhibitor
504lge_2D & B? NPS1??? Q13490PHERHomo sapiensLigase/Ligase inhibitor
504lgu_1D & A? NPS1??? Q13490PHERHomo sapiensLigase/Ligase inhibitor
504lgu_2D & B? NPS1??? Q13490PHERHomo sapiensLigase/Ligase inhibitor
504mti_1D & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
504mti_2D & B? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
504mu7_1D & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
504mu7_2D & B? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
493uw4_1D & A? NPS1??? Q13490PHERHomo sapiensApoptosis Inhibitor
472poi_1D & B? C22??? P98170PHERHomo sapiensSIGNALING PROTEIN/APOPTOSIS
472pop_1D & B? C24??? Q15750PHERHomo sapiensSIGNALING PROTEIN/APOPTOSIS
472qra_1D & C? C22??? P98170PHERHomo sapiensApoptosis, Signaling protein
472qra_2D & A? C22??? P98170PHERHomo sapiensApoptosis, Signaling protein
474mtz_1D & D? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
474mtz_2D & B? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
474oxc_1D & A? NPS1??? P98170PHERHomo sapiensLIGASE
474oxc_2D & B? NPS1??? P98170PHERHomo sapiensLIGASE
474oxc_3D & C? NPS1??? P98170PHERHomo sapiensLIGASE
474oxc_4D & D? NPS1??? P98170PHERHomo sapiensLIGASE
461g73_1D & C? NPS2??? Q9NR28PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
461g73_2D & D? NPS2??? Q9NR28PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
461nw9_1D & A? NPS2??? P98170PHERHomo sapiensAPOPTOSIS
461xb0_1D & E? C66??? Q96P09PHERHomo sapiensAPOPTOSIS
461xb1_1D & A? C66??? Q96P09PHERHomo sapiensAPOPTOSIS
461xb1_2D & O? D612??? Q96P09PHERHomo sapiensAPOPTOSIS
462jk7_1D & A? NPS1??? P98170PHERHOMO SAPIENSAPOPTOSIS
462opy_1D & A? C22??? P98170PHERHomo sapiensapoptosis activator
462opz_1D & C? C22??? P98170PHERHomo sapiensapoptosis inhibitor
462opz_2D & B? C22??? P98170PHERHomo sapiensapoptosis inhibitor
462vsl_1D & A? NPS1??? P98170PHERHOMO SAPIENSLIGASE
463clx_1D & A? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463clx_2D & B? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463clx_3D & C? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463clx_4D & D? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463clx_5D & A? C22??? P98170PHERHomo sapiensLigase, Apoptosis
463clx_6D & D? C22??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_1D & F? C22??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_10D & E? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_11D & F? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_12D & G? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_13D & H? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_14D & I? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_15D & J? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_2D & A? C22??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_3D & H? C22??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_4D & C? C22??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_5D & G? C22??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_6D & A? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_7D & B? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_8D & C? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463cm2_9D & D? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463cm7_1D & D? C22??? P98170PHERHomo sapiensLigase, Apoptosis
463cm7_2D & A? C22??? P98170PHERHomo sapiensLigase, Apoptosis
463cm7_3D & C? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463cm7_4D & A? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463cm7_5D & B? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463cm7_6D & D? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
463eyl_1D & A? C22??? P98170PHERHomo sapiensLIGASE
463g76_1D & A? NPS1??? P98170PHERHomo sapiensLIGASE
463g76_2D & B? NPS1??? P98170PHERHomo sapiensLIGASE
463g76_3D & C? NPS1??? P98170PHERHomo sapiensLIGASE
463g76_4D & D? NPS1??? P98170PHERHomo sapiensLIGASE
463g76_5D & E? NPS1??? P98170PHERHomo sapiensLIGASE
463g76_6D & F? NPS1??? P98170PHERHomo sapiensLIGASE
463g76_7D & G? NPS1??? P98170PHERHomo sapiensLIGASE
463g76_8D & H? NPS1??? P98170PHERHomo sapiensLIGASE
463hl5_1D & A? NPS1??? P98170PHERHomo sapiensLIGASE
463hl5_2D & B? NPS1??? P98170PHERHomo sapiensLIGASE
464ec4_1D & A? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
464ec4_2D & G? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
464ec4_3D & C? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
464ec4_4D & D? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
464ec4_5D & L? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
464hy0_1D & B? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
464hy0_2D & H? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
464hy0_3D & E? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
464hy0_4D & G? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
464kmp_1D & A? NPS1??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
464kmp_2D & B? NPS1??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
442uvl_1D & A? NPS1??? 2UVLPHERHOMO SAPIENSMETAL-BINDING PROTEIN
442uvl_2D & B? NPS1??? 2UVLPHERHOMO SAPIENSMETAL-BINDING PROTEIN
421jd4_1D & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS
421jd4_2D & BPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS
421jd5_1D & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterHydrolase/Peptide
421jd6_1D & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterHydrolase/Peptide
421oxn_1D & A? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxn_10D & A? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxn_11D & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxn_2D & B? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxn_3D & C? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxn_4D & D? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxn_5D & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxn_6D & A? NS5??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxn_7D & A? NS3??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxn_8D & C? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxn_9D & D? NS2??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxq_1D & A? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxq_10D & A? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxq_11D & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxq_2D & B? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxq_3D & C? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxq_4D & D? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxq_5D & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxq_6D & A? NS5??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxq_7D & D? NS3??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxq_8D & C? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oxq_9D & D? NS2??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oy7_1D & A? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oy7_2D & B? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oy7_3D & C? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oy7_4D & D? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oy7_5D & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oy7_6D & D? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oy7_7D & B? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421oy7_8D & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
421q4q_1D & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
421q4q_10D & JPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
421q4q_2D & BPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
421q4q_3D & CPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
421q4q_4D & DPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
421q4q_5D & EPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
421q4q_6D & FPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
421q4q_7D & GPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
421q4q_8D & HPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
421q4q_9D & IPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
423f7g_1D & A? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
423f7g_2D & B? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
423f7g_3D & C? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
423f7g_4D & D? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
423f7g_5D & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
423f7g_6D & A? C24??? Q96CA5PHERHomo sapiensAPOPTOSIS
411i3o_1D & F? C26??? P42574PHERHomo sapiensAPOPTOSIS
414j3y_1D & A? C22??? P98170PHERHomo sapiensAPOPTOSIS
414j44_1D & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
414j44_2D & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
414j45_1D & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
414j45_2D & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
414j46_1D & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
414j46_2D & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
414j47_1D & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
414j47_2D & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
414j48_1D & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
414j48_2D & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
414kju_1D & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
414kju_2D & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
414kjv_1D & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
414kjv_2D & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
414wvt_1D & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
414wvt_2D & B? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
414wvu_1D & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
401tw6_1D & A? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
401tw6_2D & B? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
401tw6_3D & A? C24??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
401tw6_4D & A? NS2??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
401tw6_5D & A? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
402i3h_1D & A? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
402i3h_2D & B? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
402i3h_3D & A? C24??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
402i3h_4D & A? NS2??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
402i3h_5D & A? C24??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
402i3h_6D & A? C24??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
402i3h_7D & A? NS2??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
402i3i_1D & A? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
402i3i_2D & B? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
402vm5_1D & A? NPS1??? 2VM5PHERHOMO SAPIENSAPOPTOSIS
403f7h_1D & A? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
403f7h_2D & B? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
403f7i_1D & A? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
403f7i_2D & B? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
403gt9_1D & A? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
403gt9_2D & B? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
403gta_1D & A? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
403gta_2D & B? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
403uw5_1D & A? NPS1??? Q96CA5PHERHomo sapiensApoptosis Inhibitor
403uw5_2D & B? NPS1??? Q96CA5PHERHomo sapiensApoptosis Inhibitor
1003m0a_1D & D? NPS4??? Q12933PHERHomo sapiensSIGNALING PROTEIN
1003m0d_1D & D? NPS4??? Q12933PHERHomo sapiensSIGNALING PROTEIN
361sdz_1D & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS
361se0_1D & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS
363sip_1D & F? D212??? O01382PHER0HYDROLASE/LIGASE/HYDROLASE
363sip_2D & F? C26??? O01382PHER0HYDROLASE/LIGASE/HYDROLASE
363siq_1D & A? NPS1??? Q24306PHER0LIGASE
363siq_2D & B? NPS1??? Q24306PHER0LIGASE
363siq_3D & C? NPS1??? Q24306PHER0LIGASE
363siq_4D & D? NPS1??? Q24306PHER0LIGASE
363siq_5D & E? NPS1??? Q24306PHER0LIGASE
363siq_6D & F? NPS1??? Q24306PHER0LIGASE
321e31_1D & ANO C22C22? O15392PHERHOMO SAPIENSAPOPTOSIS INHIBITOR
321f3h_1D & ANO C22C22? O15392PHERHomo sapiensAPOPTOSIS
322qfa_1D & A? NPS3??? O15392PHERHomo sapiensCell cycle/Cell cycle/Cell cycle
322raw_1D & A? NPS2??? O15392PHERHomo sapiensCELL CYCLE
322rax_1D & A? NPS2??? O15392PHERHomo sapiensCELL CYCLE
322rax_2D & E? NPS2??? O15392PHERHomo sapiensCELL CYCLE
322rax_3D & X? NPS2??? O15392PHERHomo sapiensCELL CYCLE
323uec_1D & A? C22??? O15392PHERHomo sapiensCELL CYCLE
323ued_1D & C? C22??? O15392PHERHomo sapiensCELL CYCLE
323uee_1D & A? C22??? O15392PHERHomo sapiensCELL CYCLE
323uef_1D & A? C22??? O15392PHERHomo sapiensCELL CYCLE
323ueg_1D & A? C22??? O15392PHERHomo sapiensCELL CYCLE
323ueh_1D & A? C22??? O15392PHERHomo sapiensCELL CYCLE
323uei_1D & A? C22??? O15392PHERHomo sapiensCELL CYCLE
323uig_1D & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
323uih_1D & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
323uii_1D & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
323uij_1D & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
323uik_1D & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
324a0i_1D & B? C22??? O15392PHER0CELL CYCLE
324a0j_1D & A? NPS1??? O15392PHER0CELL CYCLE
324a0j_2D & B? NPS1??? O15392PHER0CELL CYCLE
324a0n_1D & A? NPS1??? O15392PHER0CELL CYCLE
301m4m_1D & AYES NPS1C22? O70201PHERMus musculusAPOPTOSIS
301m4m_2D & ANO C22C22? O70201PHERMus musculusAPOPTOSIS
301m4m_3D & ANO C22C22? O70201PHERMus musculusAPOPTOSIS