Legend

%id Code Chains Pic Error? Sym Nsub Sprot Weight Ref H E R Org Fun
% seq. id. PDB Code query & target Graph picture Is the current PDB state judged to be an error? Symmetry No. subunits SwissProt link No. of amino acids (per chain) Pubmed ID Get Homologs Edit Structure View structure Organism Function
NOTE: roll over NO, PROBNOT or YES, PROBYES to read PiQSi annotation, and roll over the PDB name to read its title.

Protein reference

Code Pic Error? Sym1 Nsub1 Sym2 Nsub2 Error_auto? Sym_auto Nsub_auto SProt Weight Ref H E R Org Fun
PDBPiQSi
3f7g_5? NPS1??- --Q96CA5PHERHomo sapiensAPOPTOSIS

Homologs

%id Code Chains Pic Error? Sym1 Nsub1 Sym2 Nsub2 Error_auto Sym_auto Nsub_auto SProt Weight Ref H E R Org Fun
1003f7g_1E & A? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
1003f7g_2E & B? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
1003f7g_3E & C? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
1003f7g_4E & D? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
1003f7g_6E & A? C24??? Q96CA5PHERHomo sapiensAPOPTOSIS
991oxn_1E & A? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_10E & A? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_11E & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_2E & B? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_3E & C? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_4E & D? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_5E & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_6E & A? NS5??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_7E & A? NS3??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_8E & C? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_9E & D? NS2??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_1E & A? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_10E & A? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_11E & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_2E & B? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_3E & C? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_4E & D? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_5E & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_6E & A? NS5??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_7E & D? NS3??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_8E & C? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_9E & D? NS2??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_1E & A? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_2E & B? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_3E & C? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_4E & D? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_5E & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_6E & D? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_7E & B? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_8E & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
922i3h_1E & A? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3h_2E & B? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3h_3E & A? C24??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3h_4E & A? NS2??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3h_5E & A? C24??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3h_6E & A? C24??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3h_7E & A? NS2??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3i_1E & A? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3i_2E & B? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
923f7h_1E & A? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923f7h_2E & B? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923f7i_1E & A? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923f7i_2E & B? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923gt9_1E & A? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923gt9_2E & B? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923gta_1E & A? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923gta_2E & B? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
911tw6_1E & A? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
911tw6_2E & B? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
911tw6_3E & A? C24??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
911tw6_4E & A? NS2??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
911tw6_5E & A? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
913uw5_1E & A? NPS1??? Q96CA5PHERHomo sapiensApoptosis Inhibitor
913uw5_2E & B? NPS1??? Q96CA5PHERHomo sapiensApoptosis Inhibitor
582vm5_1E & A? NPS1??? 2VM5PHERHOMO SAPIENSAPOPTOSIS
513uw4_1E & A? NPS1??? Q13490PHERHomo sapiensApoptosis Inhibitor
503mup_1E & A? C24??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
503oz1_1E & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
503oz1_2E & B? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
503oz1_3E & C? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
503oz1_4E & D? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
504eb9_1E & A? C22??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
504eb9_2E & D? C22??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
504kmn_1E & A? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
482uvl_1E & A? NPS1??? 2UVLPHERHOMO SAPIENSMETAL-BINDING PROTEIN
482uvl_2E & B? NPS1??? 2UVLPHERHOMO SAPIENSMETAL-BINDING PROTEIN
471i3o_1E & F? C26??? P42574PHERHomo sapiensAPOPTOSIS
473d9t_1E & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS
473d9t_2E & B? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS
473d9u_1E & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS
474hy4_1E & A? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
474hy4_2E & B? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
474hy5_1E & A? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
474hy5_2E & B? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
474j3y_1E & A? C22??? P98170PHERHomo sapiensAPOPTOSIS
474j44_1E & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j44_2E & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j45_1E & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j45_2E & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j46_1E & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j46_2E & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j47_1E & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j47_2E & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j48_1E & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j48_2E & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474kju_1E & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
474kju_2E & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
474kjv_1E & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
474kjv_2E & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
474lge_1E & A? NPS1??? Q13490PHERHomo sapiensLigase/Ligase inhibitor
474lge_2E & B? NPS1??? Q13490PHERHomo sapiensLigase/Ligase inhibitor
474lgu_1E & A? NPS1??? Q13490PHERHomo sapiensLigase/Ligase inhibitor
474lgu_2E & B? NPS1??? Q13490PHERHomo sapiensLigase/Ligase inhibitor
474mti_1E & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
474mti_2E & B? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
474mu7_1E & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
474mu7_2E & B? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
474wvt_1E & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474wvt_2E & B? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474wvu_1E & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
451g73_1E & C? NPS2??? Q9NR28PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
451g73_2E & D? NPS2??? Q9NR28PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
451nw9_1E & A? NPS2??? P98170PHERHomo sapiensAPOPTOSIS
452jk7_1E & A? NPS1??? P98170PHERHOMO SAPIENSAPOPTOSIS
452opy_1E & A? C22??? P98170PHERHomo sapiensapoptosis activator
452opz_1E & C? C22??? P98170PHERHomo sapiensapoptosis inhibitor
452opz_2E & B? C22??? P98170PHERHomo sapiensapoptosis inhibitor
453clx_1E & A? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453clx_2E & B? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453clx_3E & C? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453clx_4E & D? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453clx_5E & A? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453clx_6E & D? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_1E & F? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_10E & E? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_11E & F? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_12E & G? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_13E & H? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_14E & I? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_15E & J? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_2E & A? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_3E & H? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_4E & C? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_5E & G? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_6E & A? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_7E & B? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_8E & C? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_9E & D? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm7_1E & D? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm7_2E & A? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm7_3E & C? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm7_4E & A? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm7_5E & B? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm7_6E & D? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453eyl_1E & A? C22??? P98170PHERHomo sapiensLIGASE
453g76_1E & A? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_2E & B? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_3E & C? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_4E & D? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_5E & E? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_6E & F? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_7E & G? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_8E & H? NPS1??? P98170PHERHomo sapiensLIGASE
454ec4_1E & A? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
454ec4_2E & G? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
454ec4_3E & C? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
454ec4_4E & D? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
454ec4_5E & L? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
454hy0_1E & B? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
454hy0_2E & H? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
454hy0_3E & E? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
454hy0_4E & G? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
454kmp_1E & A? NPS1??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
454kmp_2E & B? NPS1??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
443hl5_1E & A? NPS1??? P98170PHERHomo sapiensLIGASE
443hl5_2E & B? NPS1??? P98170PHERHomo sapiensLIGASE
431xb0_1E & E? C66??? Q96P09PHERHomo sapiensAPOPTOSIS
431xb1_1E & A? C66??? Q96P09PHERHomo sapiensAPOPTOSIS
431xb1_2E & O? D612??? Q96P09PHERHomo sapiensAPOPTOSIS
432qra_1E & C? C22??? P98170PHERHomo sapiensApoptosis, Signaling protein
432qra_2E & A? C22??? P98170PHERHomo sapiensApoptosis, Signaling protein
432vsl_1E & A? NPS1??? P98170PHERHOMO SAPIENSLIGASE
421sdz_1E & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS
421se0_1E & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS
423m0a_1E & D? NPS4??? Q12933PHERHomo sapiensSIGNALING PROTEIN
423m0d_1E & D? NPS4??? Q12933PHERHomo sapiensSIGNALING PROTEIN
423m0d_2E & D? NPS4??? Q12933PHERHomo sapiensSIGNALING PROTEIN
423sip_1E & F? D212??? O01382PHER0HYDROLASE/LIGASE/HYDROLASE
423sip_2E & F? C26??? O01382PHER0HYDROLASE/LIGASE/HYDROLASE
423siq_1E & A? NPS1??? Q24306PHER0LIGASE
423siq_2E & B? NPS1??? Q24306PHER0LIGASE
423siq_3E & C? NPS1??? Q24306PHER0LIGASE
423siq_4E & D? NPS1??? Q24306PHER0LIGASE
423siq_5E & E? NPS1??? Q24306PHER0LIGASE
423siq_6E & F? NPS1??? Q24306PHER0LIGASE
424mtz_1E & D? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
424mtz_2E & B? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
424oxc_1E & A? NPS1??? P98170PHERHomo sapiensLIGASE
424oxc_2E & B? NPS1??? P98170PHERHomo sapiensLIGASE
424oxc_3E & C? NPS1??? P98170PHERHomo sapiensLIGASE
424oxc_4E & D? NPS1??? P98170PHERHomo sapiensLIGASE
413m1d_1E & A? NPS1??? Q13490PHERHomo sapiensMETAL BINDING PROTEIN
413m1d_2E & B? NPS1??? Q13490PHERHomo sapiensMETAL BINDING PROTEIN
402poi_1E & B? C22??? P98170PHERHomo sapiensSIGNALING PROTEIN/APOPTOSIS
402pop_1E & B? C24??? Q15750PHERHomo sapiensSIGNALING PROTEIN/APOPTOSIS
381e31_1E & ANO C22C22? O15392PHERHOMO SAPIENSAPOPTOSIS INHIBITOR
381f3h_1E & ANO C22C22? O15392PHERHomo sapiensAPOPTOSIS
381jd4_1E & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS
381jd4_2E & BPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS
381jd5_1E & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterHydrolase/Peptide
381jd6_1E & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterHydrolase/Peptide
381q4q_1E & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_10E & JPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_2E & BPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_3E & CPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_4E & DPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_5E & EPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_6E & FPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_7E & GPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_8E & HPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_9E & IPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
382qfa_1E & A? NPS3??? O15392PHERHomo sapiensCell cycle/Cell cycle/Cell cycle
382raw_1E & A? NPS2??? O15392PHERHomo sapiensCELL CYCLE
382rax_1E & A? NPS2??? O15392PHERHomo sapiensCELL CYCLE
382rax_2E & E? NPS2??? O15392PHERHomo sapiensCELL CYCLE
382rax_3E & X? NPS2??? O15392PHERHomo sapiensCELL CYCLE
383uec_1E & A? C22??? O15392PHERHomo sapiensCELL CYCLE
383ued_1E & C? C22??? O15392PHERHomo sapiensCELL CYCLE
383uee_1E & A? C22??? O15392PHERHomo sapiensCELL CYCLE
383uef_1E & A? C22??? O15392PHERHomo sapiensCELL CYCLE
383ueg_1E & A? C22??? O15392PHERHomo sapiensCELL CYCLE
383ueh_1E & A? C22??? O15392PHERHomo sapiensCELL CYCLE
383uei_1E & A? C22??? O15392PHERHomo sapiensCELL CYCLE
384a0i_1E & B? C22??? O15392PHER0CELL CYCLE
384a0j_1E & A? NPS1??? O15392PHER0CELL CYCLE
384a0j_2E & B? NPS1??? O15392PHER0CELL CYCLE
384a0n_1E & A? NPS1??? O15392PHER0CELL CYCLE
371m4m_1E & AYES NPS1C22? O70201PHERMus musculusAPOPTOSIS
371m4m_2E & ANO C22C22? O70201PHERMus musculusAPOPTOSIS
371m4m_3E & ANO C22C22? O70201PHERMus musculusAPOPTOSIS
373uij_1E & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
373uik_1E & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
363uig_1E & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
363uih_1E & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
363uii_1E & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR