Legend

%id Code Chains Pic Error? Sym Nsub Sprot Weight Ref H E R Org Fun
% seq. id. PDB Code query & target Graph picture Is the current PDB state judged to be an error? Symmetry No. subunits SwissProt link No. of amino acids (per chain) Pubmed ID Get Homologs Edit Structure View structure Organism Function
NOTE: roll over NO, PROBNOT or YES, PROBYES to read PiQSi annotation, and roll over the PDB name to read its title.

Protein reference

Code Pic Error? Sym1 Nsub1 Sym2 Nsub2 Error_auto? Sym_auto Nsub_auto SProt Weight Ref H E R Org Fun
PDBPiQSi
3f7g_6? C24??- --Q96CA5PHERHomo sapiensAPOPTOSIS

Homologs

%id Code Chains Pic Error? Sym1 Nsub1 Sym2 Nsub2 Error_auto Sym_auto Nsub_auto SProt Weight Ref H E R Org Fun
1003f7g_1A & A? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
1003f7g_2A & B? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
1003f7g_3A & C? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
1003f7g_4A & D? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
1003f7g_5A & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS
991oxn_1A & A? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_10A & A? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_11A & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_2A & B? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_3A & C? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_4A & D? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_5A & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_6A & A? NS5??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_7A & A? NS3??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_8A & C? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxn_9A & D? NS2??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_1A & A? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_10A & A? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_11A & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_2A & B? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_3A & C? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_4A & D? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_5A & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_6A & A? NS5??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_7A & D? NS3??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_8A & C? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oxq_9A & D? NS2??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_1A & A? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_2A & B? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_3A & C? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_4A & D? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_5A & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_6A & D? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_7A & B? C22??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
991oy7_8A & E? NPS1??? Q96CA5PHERHomo sapiensAPOPTOSIS/peptide
922i3h_1A & A? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3h_2A & B? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3h_3A & A? C24??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3h_4A & A? NS2??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3h_5A & A? C24??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3h_6A & A? C24??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3h_7A & A? NS2??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3i_1A & A? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
922i3i_2A & B? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
923f7h_1A & A? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923f7h_2A & B? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923f7i_1A & A? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923f7i_2A & B? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923gt9_1A & A? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923gt9_2A & B? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923gta_1A & A? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
923gta_2A & B? NPS1??? Q6R308PHERHomo sapiensAPOPTOSIS
911tw6_1A & A? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
911tw6_2A & B? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
911tw6_3A & A? C24??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
911tw6_4A & A? NS2??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
911tw6_5A & A? NPS1??? Q96CA5PHERHomo sapiensINHIBITOR/APOPTOSIS
913uw5_1A & A? NPS1??? Q96CA5PHERHomo sapiensApoptosis Inhibitor
913uw5_2A & B? NPS1??? Q96CA5PHERHomo sapiensApoptosis Inhibitor
582vm5_1A & A? NPS1??? 2VM5PHERHOMO SAPIENSAPOPTOSIS
513uw4_1A & A? NPS1??? Q13490PHERHomo sapiensApoptosis Inhibitor
503mup_1A & A? C24??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
503oz1_1A & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
503oz1_2A & B? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
503oz1_3A & C? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
503oz1_4A & D? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
504eb9_1A & A? C22??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
504eb9_2A & D? C22??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
504kmn_1A & A? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
482uvl_1A & A? NPS1??? 2UVLPHERHOMO SAPIENSMETAL-BINDING PROTEIN
482uvl_2A & B? NPS1??? 2UVLPHERHOMO SAPIENSMETAL-BINDING PROTEIN
471i3o_1A & F? C26??? P42574PHERHomo sapiensAPOPTOSIS
473d9t_1A & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS
473d9t_2A & B? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS
473d9u_1A & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS
474hy4_1A & A? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
474hy4_2A & B? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
474hy5_1A & A? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
474hy5_2A & B? NPS1??? Q13490PHERHomo sapiensLIGASE/LIGASE INHIBITOR
474j3y_1A & A? C22??? P98170PHERHomo sapiensAPOPTOSIS
474j44_1A & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j44_2A & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j45_1A & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j45_2A & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j46_1A & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j46_2A & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j47_1A & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j47_2A & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j48_1A & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474j48_2A & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474kju_1A & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
474kju_2A & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
474kjv_1A & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
474kjv_2A & C? NPS1??? P98170PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
474lge_1A & A? NPS1??? Q13490PHERHomo sapiensLigase/Ligase inhibitor
474lge_2A & B? NPS1??? Q13490PHERHomo sapiensLigase/Ligase inhibitor
474lgu_1A & A? NPS1??? Q13490PHERHomo sapiensLigase/Ligase inhibitor
474lgu_2A & B? NPS1??? Q13490PHERHomo sapiensLigase/Ligase inhibitor
474mti_1A & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
474mti_2A & B? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
474mu7_1A & A? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
474mu7_2A & B? NPS1??? Q13490PHERHomo sapiensAPOPTOSIS INHIBITOR
474wvt_1A & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474wvt_2A & B? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
474wvu_1A & A? NPS1??? P98170PHERHomo sapiensAPOPTOSIS
451g73_1A & C? NPS2??? Q9NR28PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
451g73_2A & D? NPS2??? Q9NR28PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
451nw9_1A & A? NPS2??? P98170PHERHomo sapiensAPOPTOSIS
452jk7_1A & A? NPS1??? P98170PHERHOMO SAPIENSAPOPTOSIS
452opy_1A & A? C22??? P98170PHERHomo sapiensapoptosis activator
452opz_1A & C? C22??? P98170PHERHomo sapiensapoptosis inhibitor
452opz_2A & B? C22??? P98170PHERHomo sapiensapoptosis inhibitor
453clx_1A & A? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453clx_2A & B? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453clx_3A & C? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453clx_4A & D? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453clx_5A & A? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453clx_6A & D? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_1A & F? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_10A & E? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_11A & F? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_12A & G? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_13A & H? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_14A & I? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_15A & J? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_2A & A? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_3A & H? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_4A & C? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_5A & G? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_6A & A? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_7A & B? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_8A & C? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm2_9A & D? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm7_1A & D? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm7_2A & A? C22??? P98170PHERHomo sapiensLigase, Apoptosis
453cm7_3A & C? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm7_4A & A? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm7_5A & B? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453cm7_6A & D? NPS1??? P98170PHERHomo sapiensLigase, Apoptosis
453eyl_1A & A? C22??? P98170PHERHomo sapiensLIGASE
453g76_1A & A? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_2A & B? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_3A & C? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_4A & D? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_5A & E? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_6A & F? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_7A & G? NPS1??? P98170PHERHomo sapiensLIGASE
453g76_8A & H? NPS1??? P98170PHERHomo sapiensLIGASE
454ec4_1A & A? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
454ec4_2A & G? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
454ec4_3A & C? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
454ec4_4A & D? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
454ec4_5A & L? C22??? P98170PHERHomo sapiensAPOPTOSIS INHIBITOR
454hy0_1A & B? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
454hy0_2A & H? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
454hy0_3A & E? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
454hy0_4A & G? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
454kmp_1A & A? NPS1??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
454kmp_2A & B? NPS1??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
443hl5_1A & A? NPS1??? P98170PHERHomo sapiensLIGASE
443hl5_2A & B? NPS1??? P98170PHERHomo sapiensLIGASE
431xb0_1A & E? C66??? Q96P09PHERHomo sapiensAPOPTOSIS
431xb1_1A & A? C66??? Q96P09PHERHomo sapiensAPOPTOSIS
431xb1_2A & O? D612??? Q96P09PHERHomo sapiensAPOPTOSIS
432qra_1A & C? C22??? P98170PHERHomo sapiensApoptosis, Signaling protein
432qra_2A & A? C22??? P98170PHERHomo sapiensApoptosis, Signaling protein
432vsl_1A & A? NPS1??? P98170PHERHOMO SAPIENSLIGASE
421sdz_1A & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS
421se0_1A & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS
423m0a_1A & D? NPS4??? Q12933PHERHomo sapiensSIGNALING PROTEIN
423m0d_1A & D? NPS4??? Q12933PHERHomo sapiensSIGNALING PROTEIN
423m0d_2A & D? NPS4??? Q12933PHERHomo sapiensSIGNALING PROTEIN
423sip_1A & F? D212??? O01382PHER0HYDROLASE/LIGASE/HYDROLASE
423sip_2A & F? C26??? O01382PHER0HYDROLASE/LIGASE/HYDROLASE
423siq_1A & A? NPS1??? Q24306PHER0LIGASE
423siq_2A & B? NPS1??? Q24306PHER0LIGASE
423siq_3A & C? NPS1??? Q24306PHER0LIGASE
423siq_4A & D? NPS1??? Q24306PHER0LIGASE
423siq_5A & E? NPS1??? Q24306PHER0LIGASE
423siq_6A & F? NPS1??? Q24306PHER0LIGASE
424mtz_1A & D? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
424mtz_2A & B? C22??? P98170PHERHomo sapiensLIGASE/LIGASE INHIBITOR
424oxc_1A & A? NPS1??? P98170PHERHomo sapiensLIGASE
424oxc_2A & B? NPS1??? P98170PHERHomo sapiensLIGASE
424oxc_3A & C? NPS1??? P98170PHERHomo sapiensLIGASE
424oxc_4A & D? NPS1??? P98170PHERHomo sapiensLIGASE
413m1d_1A & A? NPS1??? Q13490PHERHomo sapiensMETAL BINDING PROTEIN
413m1d_2A & B? NPS1??? Q13490PHERHomo sapiensMETAL BINDING PROTEIN
402poi_1A & B? C22??? P98170PHERHomo sapiensSIGNALING PROTEIN/APOPTOSIS
402pop_1A & B? C24??? Q15750PHERHomo sapiensSIGNALING PROTEIN/APOPTOSIS
381e31_1A & ANO C22C22? O15392PHERHOMO SAPIENSAPOPTOSIS INHIBITOR
381f3h_1A & ANO C22C22? O15392PHERHomo sapiensAPOPTOSIS
381jd4_1A & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS
381jd4_2A & BPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS
381jd5_1A & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterHydrolase/Peptide
381jd6_1A & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterHydrolase/Peptide
381q4q_1A & APROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_10A & JPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_2A & BPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_3A & CPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_4A & DPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_5A & EPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_6A & FPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_7A & GPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_8A & HPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
381q4q_9A & IPROBNOT NPS1NPS1? Q24306PHERDrosophila melanogasterAPOPTOSIS INHIBITOR
382qfa_1A & A? NPS3??? O15392PHERHomo sapiensCell cycle/Cell cycle/Cell cycle
382raw_1A & A? NPS2??? O15392PHERHomo sapiensCELL CYCLE
382rax_1A & A? NPS2??? O15392PHERHomo sapiensCELL CYCLE
382rax_2A & E? NPS2??? O15392PHERHomo sapiensCELL CYCLE
382rax_3A & X? NPS2??? O15392PHERHomo sapiensCELL CYCLE
383uec_1A & A? C22??? O15392PHERHomo sapiensCELL CYCLE
383ued_1A & C? C22??? O15392PHERHomo sapiensCELL CYCLE
383uee_1A & A? C22??? O15392PHERHomo sapiensCELL CYCLE
383uef_1A & A? C22??? O15392PHERHomo sapiensCELL CYCLE
383ueg_1A & A? C22??? O15392PHERHomo sapiensCELL CYCLE
383ueh_1A & A? C22??? O15392PHERHomo sapiensCELL CYCLE
383uei_1A & A? C22??? O15392PHERHomo sapiensCELL CYCLE
384a0i_1A & B? C22??? O15392PHER0CELL CYCLE
384a0j_1A & A? NPS1??? O15392PHER0CELL CYCLE
384a0j_2A & B? NPS1??? O15392PHER0CELL CYCLE
384a0n_1A & A? NPS1??? O15392PHER0CELL CYCLE
371m4m_1A & AYES NPS1C22? O70201PHERMus musculusAPOPTOSIS
371m4m_2A & ANO C22C22? O70201PHERMus musculusAPOPTOSIS
371m4m_3A & ANO C22C22? O70201PHERMus musculusAPOPTOSIS
373uij_1A & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
373uik_1A & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
363uig_1A & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
363uih_1A & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR
363uii_1A & A? C22??? O15392PHERHomo sapiensAPOPTOSIS/APOPTOSIS INHIBITOR